Emergingby Glyph
Loyal
Veterinary drug company developing FDA-approved lifespan extension drugs for dogs.
Longevity biotechloyal.com
Companies in frontier tech
22 of 403 companies
Insilico Medicine
Generative AI drug discovery company that tests candidates such as rentosertib against aging clocks.
Longevity biotechinsilico.com
Life Biosciences
Develops partial epigenetic reprogramming therapies using OSK factors, led by ER-100 for optic neuropathies.
Longevity biotechlifebiosciences.com
Calico Life Sciences
Alphabet-founded company researching the biology of aging and developing drugs for age-related diseases.
Longevity biotechcalicolabs.com
Nexo Therapeutics
Covalent small molecule discovery company working with Calico on targets for age-related diseases.
Longevity biotechnexotx.com
BioAge Labs
Uses human aging biology to develop cardiometabolic drugs, including the NLRP3 inhibitor BGE-102.
Longevity biotechbioagelabs.com
AbbVie
Partnered with Calico on aging drug research for over a decade before ending the alliance in 2025.
Longevity biotech, Nanotechnologyabbvie.com
Unity Biotechnology
Developed senolytic drugs such as UBX1325 for eye disease; stockholders approved its dissolution in 2025.
Longevity biotechunitybiotechnology.com
Altos Labs
Research company working on cellular rejuvenation programming to reverse disease.
Longevity biotechaltoslabs.com
Mabwell Bioscience
Developed the IL-11 antibody 9MW3811, explored for age-related diseases and licensed to Calico.
Longevity biotechmabwell.com
Shift Bioscience
Uses an AI virtual cell platform and aging clocks to find single-gene targets for safer cell rejuvenation.
Longevity biotechshiftbioscience.com
Cambrian Bio
Clinical-stage company developing drugs that target metabolic pathways that decline with age, such as AMPK and mTOR.
Longevity biotechcambrianbio.com
clock.health
Formerly clock.bio; builds science and tools to measure and rejuvenate human cells and tissues.
Longevity biotechclock.health
Eli Lilly
Invested in NewLimit's 2025 extension round through Eli Lilly and Company.
Longevity biotechlilly.com
Gordian Biotechnology
Uses an in vivo drug discovery platform to find targets and therapies for complex age-related diseases.
Longevity biotechgordian.bio
Hevolution Foundation
Funds research, grants and company investments to extend healthy human lifespan.
Longevity biotechhevolution.com
Junevity
Develops siRNA therapeutics that reset gene networks to reverse disease.
Longevity biotechjunevity.com
Juvenescence
Develops medicines that target core aging mechanisms to treat and prevent age-related diseases.
Longevity biotechjuvlabs.com
NewLimit
Develops epigenetic reprogramming medicines to restore youthful function in old cells, starting with the liver.
Longevity biotechnewlimit.com
Rejuvenate Bio
Develops gene therapies for chronic age-related disease in companion animals and humans.
Longevity biotechrejuvenatebio.com
Retro Biosciences
Develops autophagy drugs, iPSC-derived cell therapies and tissue reprogramming aimed at adding ten healthy years.
Longevity biotechretro.bio
Rubedo Life Sciences
Develops drugs that target senescent cells, led by the topical GPX4 modulator RLS-1496.
Longevity biotechrubedolife.com