Emergingby GlyphOxidative Stress-Driven Cellular Senescence: Mechanistic Crosstalk and Therapeutic Horizons
Bojan Stojanović, Bojan Stojanovic, Ivan Jovanovic et al. · Antioxidants
Longevity biotech
Papers in frontier tech
35 papers
Hallmarks and mechanisms of cellular senescence in aging and disease
Amir Ajoolabady, Domenico Praticò, Suhad Bahijri et al. · Cell Death Discovery
Longevity biotech
Hallmarks of cellular senescence: biology, mechanisms, regulations
Amir Ajoolabady, Domenico Praticò, Suhad Bahijri et al. · Experimental & Molecular Medicine
Longevity biotech
Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids
Yifei Miao, Nicole Min Qian Pek, Cheng Peow Bobby Tan et al. · Cell
Longevity biotech
Recent advances in dermal fibroblast senescence and skin aging: unraveling mechanisms and pioneering therapeutic strategies
Nan Li, Pengchao Guo, Hui Wang et al. · Frontiers in Pharmacology
Longevity biotech
Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions
Timur M. Saliev, Prim B. Singh · Biomolecules
Longevity biotech
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages
Liyan Gong, Yadong Zhang, Yonglin Zhu et al. · Cell stem cell
Longevity biotech
Senescence in cancer
Manuel Colucci, Miles Sarill, Martino Maddalena et al. · Cancer Cell
Longevity biotech
Gastruloids enable modeling of the earliest stages of human cardiac and hepatic vascularization
Oscar John Abilez, Huaxiao Yang, Yuan Guan et al. · Science
Longevity biotech
Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects
Aitor Picos, Nuria Seoane, Manuel Campos‐Toimil et al. · Biogerontology
Longevity biotech
SASP Modulation for Cellular Rejuvenation and Tissue Homeostasis: Therapeutic Strategies and Molecular Insights
Saud Alqahtani, Taha Alqahtani, Krishnaraju Venkatesan et al. · Cells
Longevity biotech
Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s disease
Viviane S. Tabar, Harini Sarva, Andrés M. Lozano et al. · Nature
Longevity biotech
Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease
Nobukatsu Sawamoto, Daisuke Doi, Etsuro Nakanishi et al. · Nature
Longevity biotech
Multi-zonal liver organoids from human pluripotent stem cells
Hasan Al Reza, Connie Santangelo, Kentaro Iwasawa et al. · Nature
Longevity biotech
Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways
Bowei Liu, Zhigang Peng, Hao Zhang et al. · Molecular Cancer
Longevity biotech
A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s disease
Courtney L. Millar, Ike Iloputaife, Kathryn Baldyga et al. · EBioMedicine
Longevity biotech
Unveiling the cell-type-specific landscape of cellular senescence through single-cell transcriptomics using SenePy
Mark A. Sanborn, Xinge Wang, Shang Gao et al. · Nature Communications
Longevity biotech
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
Youkun Bi, Xinlong Qiao, Zhaokui Cai et al. · Cell Metabolism
Longevity biotech
Gut microbial-derived phenylacetylglutamine accelerates host cellular senescence
Hao Yang, Tongyao Wang, C.-W. Qian et al. · Nature Aging
Longevity biotech
Vascularized human brain organoids: current possibilities and prospects
Lois Kistemaker, Emma J. van Bodegraven, Helga E. de Vries et al. · Trends in biotechnology
Longevity biotech
Pluripotent stem-cell-derived therapies in clinical trial: A 2025 update
Agnete Kirkeby, Heather Main, Melissa Carpenter · Cell stem cell
Longevity biotech
Modelling human brain development and disease with organoids
Marcella Birtele, Madeline A. Lancaster, Giorgia Quadrato · Nature Reviews Molecular Cell Biology
Longevity biotech
A framework for neural organoids, assembloids and transplantation studies
Sergiu P. Pașca, Paola Arlotta, Helen S. Bateup et al. · Nature
Longevity biotech
The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus
Mina L. Kojima, Caroline Hoppe, Antonio J. Giráldez · Nature Reviews Genetics
Longevity biotech
Emerging insights in senescence: pathways from preclinical models to therapeutic innovations
Lyndon E. Mansfield, Valentina Ramponi, Kavya Gupta et al. · npj Aging
Longevity biotech
Senescence as a therapeutic target in cancer and age-related diseases
Domhnall McHugh, Imanol Durán, Jesús Gil · Nature Reviews Drug Discovery
Longevity biotech
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ
Christos Kiourtis, Maria Terradas-Terradas, Lucy Gee et al. · Nature Cell Biology
Longevity biotech
Revolutionizing medicine: recent developments and future prospects in stem-cell therapy
Bashdar Mahmud Hussen, Mohammad Naser Taheri, Raya Kh. Yashooa et al. · International Journal of Surgery
Longevity biotech
Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging
Shuai Ma, Zhejun Ji, Bin Zhang et al. · Cell
Longevity biotech
The role of the dynamic epigenetic landscape in senescence: orchestrating SASP expression
Nirmalya Dasgupta, Rouven Arnold, Anaïs Equey et al. · npj Aging
Longevity biotech
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases
Juliette Tavenier, Jan Olof Nehlin, Morten Baltzer Houlind et al. · Mechanisms of Ageing and Development
Longevity biotech
Identifying specific functional roles for senescence across cell types
Huan Zhao, Zixin Liu, Hui Chen et al. · Cell
Longevity biotech
Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases
Zeming Wu, Jing Tao Qu, Guang‐Hui Liu · Nature Reviews Molecular Cell Biology
Longevity biotech
The role of p21 in cellular senescence and aging-related diseases
Jiayu Yan, Siyi Chen, Zimei Yi et al. · Molecules and Cells
Longevity biotech
Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells
Elizabeth Ng, Gulcan Sarila, Jacky Y. Li et al. · Nature Biotechnology
Longevity biotech