Emergingby GlyphAgent-guided epitope excision enables economical de novo binder design
Jun W. Kim, Artiom Myaskovsky, Oscar Donosa et al. · arXiv q-bio.BM
Synthetic biology
Papers in frontier tech
40 papers
De novo design of monoclonal and bispecific antibodies with OFAntibody
Valhalla Team · arXiv q-bio.BM
Synthetic biology
An updated evolutionary classification of CRISPR–Cas systems including rare variants
Kira S. Makarova, Sergey Shmakov, Yuri I. Wolf et al. · Nature Microbiology
Synthetic biology
A Review of Artificial Intelligence Applications for Biorefineries and Bioprocessing: From Data-Driven Processes to Optimization Strategies and Real-Time Control
Alex Butean, Iulia Cutean, Rubén Barbero et al. · Processes
Synthetic biology
Revolutionizing CRISPR technology with artificial intelligence
Min‐Gyeong Kim, Min-ji Go, Seung-Hun Kang et al. · Experimental & Molecular Medicine
Synthetic biology
Design of highly functional genome editors by modelling CRISPR–Cas sequences
Jeffrey A. Ruffolo, Stephen Nayfach, Joseph P. Gallagher et al. · Nature
Synthetic biology
CRISPR-GPT for agentic automation of gene-editing experiments
Yuanhao Qu, Kaixuan Huang, Ming Yin et al. · Nature Biomedical Engineering
Synthetic biology
Integrated biotechnological and AI innovations for crop improvement
Guotian Li, Linna An, Wanneng Yang et al. · Nature
Synthetic biology
Off-target effects in CRISPR-Cas genome editing for human therapeutics: Progress and challenges
Nechama Kalter, Carla Fuster‐García, Alfredo Silva et al. · Molecular Therapy — Nucleic Acids
Synthetic biology
RNA chemistry and therapeutics
Siyu Wang, Drew Weissman, Yizhou Dong · Nature Reviews Drug Discovery
Synthetic biology
Advancing protein evolution with inverse folding models integrating structural and evolutionary constraints
Hongyuan Fei, Yunjia Li, Yijing Liu et al. · Cell
Synthetic biology
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease
Kiran Musunuru, Sarah A. Grandinette, Xiao Wang et al. · New England Journal of Medicine
Synthetic biology
Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase
Isaac P. Witte, George D. Lampe, Simon Eitzinger et al. · Science
Synthetic biology
Ultrasensitive detection of clinical pathogens through a target-amplification-free collateral-cleavage-enhancing CRISPR-CasΦ tool
Huiyou Chen, Fengge Song, Buhua Wang et al. · Nature Communications
Synthetic biology
Viral delivery of an RNA-guided genome editor for transgene-free germline editing in Arabidopsis
Trevor J. Weiss, Maris Kamalu, Honglue Shi et al. · Nature Plants
Synthetic biology
Custom CRISPR–Cas9 PAM variants via scalable engineering and machine learning
Rachel A. Silverstein, Nahye Kim, Ann-Sophie Helene Kroell et al. · Nature
Synthetic biology
Engineering biology applications for environmental solutions: potential and challenges
David J. Lea‐Smith, Francis Hassard, Frédéric Coulon et al. · Nature Communications
Synthetic biology
Comprehensive evaluation of the capacities of microbial cell factories
Gi Bae Kim, Ha Rim Kim, Sang Yup Lee · Nature Communications
Synthetic biology
Advances in genetically engineered microorganisms: Transforming food production through precision fermentation and synthetic biology
Seyed Mehrdad Mirsalami, Mahsa Mirsalami · Future Foods
Synthetic biology
CRISPR–Cas applications in agriculture and plant research
Aytug Tuncel, Changtian Pan, Joshua S. Clem et al. · Nature Reviews Molecular Cell Biology
Synthetic biology
Disentangling microbial interaction networks
Leonardo Oña, Shryli K Shreekar, Christian Kost · Trends in Microbiology
Synthetic biology
A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels
Frédéric Tremblay, Qiang Xiong, Shrijal S. Shah et al. · Nature Medicine
Synthetic biology
Customizable virus-like particles deliver CRISPR–Cas9 ribonucleoprotein for effective ocular neovascular and Huntington’s disease gene therapy
Sikai Ling, Xue Zhang, Yao Dai et al. · Nature Nanotechnology
Synthetic biology
Tunable control of Cas12 activity promotes universal and fast one-pot nucleic acid detection
Zhou‐Hua Cheng, Xiyan Luo, Steven L. Yu et al. · Nature Communications
Synthetic biology
Rational multienzyme architecture design with iMARS
Jiawei Wang, Xingyu Ouyang, Shiyu Meng et al. · Cell
Synthetic biology
Recent developments and future directions in point-of-care next-generation CRISPR-based rapid diagnosis
Youssef Mohamed Hassan, Ahmed S. Mohamed, Yaser M. Hassan et al. · Clinical and Experimental Medicine
Synthetic biology
Ecological design of high-performance synthetic microbial communities: from theoretical foundations to functional optimization
Zhihan Wang, Shang Wang, Qinglin He et al. · ISME Communications
Synthetic biology
Engineering source-sink relations by prime editing confers heat-stress resilience in tomato and rice
H. F. Lou, Shujia Li, Zihang Shi et al. · Cell
Synthetic biology
Synthetic biology and artificial intelligence in crop improvement
Daolei Zhang, Fan L. Xu, Fanhua Wang et al. · Plant Communications
Synthetic biology
Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine
Sarkar Sardar Azeez, Rahin Shareef Hamad, BahraK Hamad et al. · Frontiers in Genome Editing
Synthetic biology
Machine Learning-Assisted, Dual-Channel CRISPR/Cas12a Biosensor-In-Microdroplet for Amplification-Free Nucleic Acid Detection for Food Authenticity Testing
Zhiying Zhao, Roumeng Wang, Xinqi Yang et al. · ACS Nano
Synthetic biology
Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations
Rafał Hołubowicz, Samuel W. Du, Jiin H. Felgner et al. · Nature Biomedical Engineering
Synthetic biology
Rapid in silico directed evolution by a protein language model with EVOLVEpro
Kaiyi Jiang, Zhaoqing Yan, Matteo Di Bernardo et al. · Science
Synthetic biology
Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein
Kai Chen, Hesong Han, Sheng Zhao et al. · Nature Biotechnology
Synthetic biology
Split crRNA with CRISPR-Cas12a enabling highly sensitive and multiplexed detection of RNA and DNA
Yi-Chuan Chen, Xinping Wang, Junqi Zhang et al. · Nature Communications
Synthetic biology
CRISPR-Cas9-mediated homology-directed repair for precise gene editing
Hongyu Liao, Jiahao Wu, Nathan J. VanDusen et al. · Molecular Therapy — Nucleic Acids
Synthetic biology
Modern Plant Breeding Techniques in Crop Improvement and Genetic Diversity: From Molecular Markers and Gene Editing to Artificial Intelligence, A Critical Review
Lixia Sun, Mingyu Lai, Fozia Ghouri et al. · Plants
Synthetic biology
Recent advances of CRISPR-based genome editing for enhancing staple crops
Feng Chen, Chen D. Lu, Yan Q. Zhao et al. · Frontiers in Plant Science
Synthetic biology
Genetic expression in cancer research: Challenges and complexity
Hengrui Liu, Zheng yao Guo, Panpan Wang · Gene Reports
Synthetic biology
RETRACTED ARTICLE: Recent advances and challenges in single cell protein (SCP) technologies for food and feed production
Yu Pin Li, Fatemeh Ahmadi, Khalil Kariman et al. · npj Science of Food
Synthetic biology